President Jacob Zuma and ANC Deputy President Cyril Ramaphosa have visited Mr Mandela and spoken to his wife and medical teams.
"The doctors are doing everything possible to get his condition to improve and are ensuring that Madiba is well-looked after and is comfortable. He is in good hands," said President Zuma.
Mr Mandela, 94, was taken to hospital in Pretoria on June 4 for the third time this year, with a lung infection.
Mr Zuma said he had been told by doctors on Sunday that the former President's condition had worsened over the past 24 hours.
He and Mr Ramaphosa were also assured by doctors that when the ambulance transporting Mr Mandela to hospital on the 8th of June developed engine problems, all care was taken to ensure that his medical condition was not compromised.
"There were seven doctors in the convoy who were in full control of the situation throughout the period. He had expert medical care. The fully equipped military ICU ambulance had a full complement of specialist medical staff including intensive care specialists and ICU nurses. The doctors also dismissed the media reports that Madiba suffered cardiac arrest. There is no truth at all in that report," said President Zuma.
He appealed for prayers for Mr Mandela and his medical team.
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